NDNR welcomes Dr. Mikhail Friedman to discuss tauroursodeoxycholic acid (TUDCA) and its protective role against neurodegeneration, based on an NDNR neurology and mind-body issue. Friedman explains TUDCA’s origin from bear bile research related to hibernation and describes proposed mechanisms including protection against cholestasis, mitochondrial and endoplasmic reticulum stress, anti-apoptotic and anti-inflammatory effects, autophagy support, bile-acid receptor signaling, and blood-brain barrier penetration. He reviews clinical and regulatory contexts (Italy approval for cholestatic liver disease; U.S. prescription only when combined with phenylbutyrate for ALS), mixed ALS study outcomes, and case experiences in ALS, MS, COPD, Parkinson’s, biliary dyskinesia, and post-cholecystectomy memory issues.
00:00 Podcast Intro
01:12 Guest Introduction
02:01 Why TUDCA Matters
02:17 Bear Bile Origins
04:37 Human Uses and Approvals
06:17 ALS and MS Stories
09:22 More Clinical Cases
11:54 Bile Acids and Microbiome
17:03 Metabolic and ER Stress
18:54 Autophagy and Sleep
22:06 Safety and Dosing
25:17 Synergy and Future Research
26:35 Clinician Role and Wrap Up
30:01 Closing Credits
Version: 20241125
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